By Dr. Mahboob Ul Hussain
Gap-junction proteins, connexins are vital mobile entities that keep an eye on quite a few features of mobile body structure. The connexins represent huge kinfolk of proteins. the current booklet presents easy evaluate approximately a variety of elements of connexin proteins. The e-book has attempted to the touch the basic facets of connexin kinfolk. This e-book could be valuable to wide viewers that incorporates under-and post-graduate scholars, learn students, clinicians, and so on. The reference part on the finish of the ebook should be invaluable if you happen to search to understand deeper information about this kinfolk of proteins.
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Additional info for Connexins: The Gap Junction Proteins
Cx40 is involved in the propagation of electrical impulse from the atria to the ventricles. The role of Cx40 has been ascertained using knock-out mice. Mice heterozygous for Cx40 deletion possess similar electrophysiological properties as compared to wild-type mice. However, Cx40 KO null mice (Cx40−/−) show many electrophysiological disturbances. For example, the Cx40 KO mice exhibit disturbed cardiac influx propagation at various levels of the CCS and an increased incidence of inducible atrial arrhythmias.
Comparison of the 5′-UTRs of various connexin genes revealed that most of the 5′-UTRs of connexins are all much longer than 50 nucleotides. 2 MicroRNAs (miRNAs) and Translational Regulation 29 have acquired IRES elements for their efficient translation. One speculation is that connexins have a very important cellular function that requires that these proteins to be translated even under the conditions when global translation is inhibited. Indeed, IRES-mediated initiation of translation has been found in genes of proteins that need to be expressed under conditions where cap-mediated translation is impaired.
Thus, reduction of Cx43 expression, and consequently the electrical coupling, may play a critical role in ventricular arrhythmogenesis. Remodelling of Cx43, during acute ischaemia, is known to be the primary cause of developing arrhythmogenesis. The Cx40 is expressed in the fetal and neonatal ventricles; however, its expression goes down drastically during the adult stages. Low levels of Cx40 expression have also been found in the SA node and AV node. Cx40 is involved in the propagation of electrical impulse from the atria to the ventricles.
Connexins: The Gap Junction Proteins by Dr. Mahboob Ul Hussain