Computational Neuroscience: Simulated Demyelinating - download pdf or read online

By Diana Ivanova Stephanova

ISBN-10: 1466578327

ISBN-13: 9781466578326

ISBN-10: 146657836X

ISBN-13: 9781466578364

''Preface Preface v vi Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies (PISD) are specifi c symptoms for CIDP and its subtypes; (3) the serious focal demyelinations, each one of them internodal and paranodal, paranodalinternodal (IFD and PFD, PIFD), are specifi c signs for received demyelinating neuropathies resembling GBS and MMN; (4) the simulated steadily higher levels of Read more...

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By Diana Ivanova Stephanova

ISBN-10: 1466578327

ISBN-13: 9781466578326

ISBN-10: 146657836X

ISBN-13: 9781466578364

''Preface Preface v vi Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies (PISD) are specifi c symptoms for CIDP and its subtypes; (3) the serious focal demyelinations, each one of them internodal and paranodal, paranodalinternodal (IFD and PFD, PIFD), are specifi c signs for received demyelinating neuropathies resembling GBS and MMN; (4) the simulated steadily higher levels of Read more...

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Additional resources for Computational Neuroscience: Simulated Demyelinating Neuropathies and Neuronopathies

Example text

A critical diagnostic feature of GBS and MMN is the demonstration of conduction block in multiple peripheral nerves on electrophysiological investigations (Kiernan et al. 2002, Kuwabara et al. 2002, Kaji 2003, Priori et al. 2005). Such a block was also demonstrated here in the IFD, PFD and PIFD cases. The simulated almost normal amplitudes and durations of action potentials and their near normal conduction velocities in the simulated ALS subtypes are in agreement with the slightly reduced velocities obtained for the almost normal action potentials recorded in patients with ALS (Sobue et al.

The latter is zero, as the resistive nodal gap is not taken into account in the model. However, the nodal transmembrane (external membrane) current (Im, in Fig. 6b), for all investigated cases, is less than the current across the nodal axolemma (Ia). This is because the longitudinal current flows through the paranodal seal resistance (Rpn) to the periaxonal space. 40 Computational Neuroscience: Simulated Demyelinating Neuropathies and Neuronopathies Fig. 6. Kinetics of the currents defining the action potential in the normal, ISD, PSD and PISD cases at node 10.

The kinetics of the currents in the ISD case is consistent with the effect of the uniformly reduced myelin lamellae along the fibre length and shows the mechanisms of the conduction slowing of action potentials obtained in simulated CMT1A. The kinetics of the currents in the PSD case is consistent with the effect of the uniformly reduced paranodal seal resistance along the fibre length and shows the mechanisms of the conduction slowing of action potentials obtained in simulated CIDP. The kinetics of the currents in the PISD case is consistent with the effect of the reduced myelin lamellae, additionally increased by reduced paranodal seal resistance along the fibre length and shows the mechanisms of the conduction slowing of action potentials obtained in heterogeneous demyelinations, such as in some CIDP subtypes.

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Computational Neuroscience: Simulated Demyelinating Neuropathies and Neuronopathies by Diana Ivanova Stephanova


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