Download e-book for kindle: Biochemistry of the Eye by David R. Whikehart PhD

By David R. Whikehart PhD

ISBN-10: 0750671521

ISBN-13: 9780750671521

This really good textual content provides a evaluation of common biochemistry and an in-depth exploration of biochemistry specific to the attention. As a readable advent to this demanding subject, it describes the molecular constructions and biochemical occasions that take place within the eye. particular medical examples hyperlink uncomplicated technological know-how to medical perform and supply a concrete foundation for realizing advanced options. This version comprises new, up to date info in revised chapters plus extra chapters on ocular fluids and pathology. basic biochemistry is mentioned in each one bankruptcy, with examples of biochemical pathology and illness strategies corresponding to age-related cataract formation and ocular diabetes.

  • Well-illustrated content material, that includes colour inserts with 10 illustrations, exhibits visible points of biochemistry.
  • Each bankruptcy encompasses a normal evaluate of the subject material ahead of discussing ocular biochemistry.
  • Discussions of proteins which are both designated to the attention and/or have distinctive features within the eye, akin to collagen's position within the constitution of the cornea, emphasize the significance of those compounds and their many crucial mobile and ocular functions.
  • Discussions of the character and serve as of enzymes, as well as descriptions of examples of particular enzymes present in the attention, spotlight the style during which many biochemical reactions ensue within the eye is through enzyme catalysis.
  • A bankruptcy on carbohydrates emphasizes the significance of the 2 roles of carbohydrates in ocular tissue: power offer (nutrition) and as a resource of extracellular structure.
  • An rationalization of the numerous other kinds of lipids that exist within the eye positive aspects the main updated fabric on tear movie lipids and important info on nutritional nutrition A requirements.
  • A bankruptcy on hormones bargains with the position of hormones more often than not and indicates how hormones play roles in ocular features, together with the method of visible transduction as a hormonal function.
  • A thorough assessment of nucleic acid chemistry issues out its function in molecular organic capabilities similar to DNA replication, RNA transcription, and protein translation, in addition to DNA mutations.
  • A bankruptcy on neurochemistry offers an knowing of simple neurochemistry and the way neurochemistry can clarify the complicated services of the retina.
  • The immunochemistry bankruptcy comprises uncomplicated fabric on biochemical and mobile immunology, discussing immune privilege within the eye and the significance of immune reactions on the anterior segment.
  • A new bankruptcy describes the biochemical pathology of 4 degenerative stipulations (corneal ulcers, chemical burns, glaucoma, and mobile apoptosis) to assist the clinician comprehend pathological approaches and the time process degenerative approaches and techniques of treatment.
  • A new bankruptcy on Water and Ocular Fluids bargains exact assurance of the services of eye fluids and the way drug businesses needs to layout medications for the ocular floor, evaluating the actual, chemical, and organic homes of water with fluids present in the eye.

Show description

By David R. Whikehart PhD

ISBN-10: 0750671521

ISBN-13: 9780750671521

This really good textual content provides a evaluation of common biochemistry and an in-depth exploration of biochemistry specific to the attention. As a readable advent to this demanding subject, it describes the molecular constructions and biochemical occasions that take place within the eye. particular medical examples hyperlink uncomplicated technological know-how to medical perform and supply a concrete foundation for realizing advanced options. This version comprises new, up to date info in revised chapters plus extra chapters on ocular fluids and pathology. basic biochemistry is mentioned in each one bankruptcy, with examples of biochemical pathology and illness strategies corresponding to age-related cataract formation and ocular diabetes.

  • Well-illustrated content material, that includes colour inserts with 10 illustrations, exhibits visible points of biochemistry.
  • Each bankruptcy encompasses a normal evaluate of the subject material ahead of discussing ocular biochemistry.
  • Discussions of proteins which are both designated to the attention and/or have distinctive features within the eye, akin to collagen's position within the constitution of the cornea, emphasize the significance of those compounds and their many crucial mobile and ocular functions.
  • Discussions of the character and serve as of enzymes, as well as descriptions of examples of particular enzymes present in the attention, spotlight the style during which many biochemical reactions ensue within the eye is through enzyme catalysis.
  • A bankruptcy on carbohydrates emphasizes the significance of the 2 roles of carbohydrates in ocular tissue: power offer (nutrition) and as a resource of extracellular structure.
  • An rationalization of the numerous other kinds of lipids that exist within the eye positive aspects the main updated fabric on tear movie lipids and important info on nutritional nutrition A requirements.
  • A bankruptcy on hormones bargains with the position of hormones more often than not and indicates how hormones play roles in ocular features, together with the method of visible transduction as a hormonal function.
  • A thorough assessment of nucleic acid chemistry issues out its function in molecular organic capabilities similar to DNA replication, RNA transcription, and protein translation, in addition to DNA mutations.
  • A bankruptcy on neurochemistry offers an knowing of simple neurochemistry and the way neurochemistry can clarify the complicated services of the retina.
  • The immunochemistry bankruptcy comprises uncomplicated fabric on biochemical and mobile immunology, discussing immune privilege within the eye and the significance of immune reactions on the anterior segment.
  • A new bankruptcy describes the biochemical pathology of 4 degenerative stipulations (corneal ulcers, chemical burns, glaucoma, and mobile apoptosis) to assist the clinician comprehend pathological approaches and the time process degenerative approaches and techniques of treatment.
  • A new bankruptcy on Water and Ocular Fluids bargains exact assurance of the services of eye fluids and the way drug businesses needs to layout medications for the ocular floor, evaluating the actual, chemical, and organic homes of water with fluids present in the eye.

Show description

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Additional info for Biochemistry of the Eye

Sample text

This means that the α- and β-crystallins, once synthesized, are considered to be stable. The primary structures of α- and β-crystallins are nonetheless altered, after synthesis, by the addition of phosphate groups (phosphorylation), the incorporation of sugars (glycosylation and glycation), deamidation, and possible degradation of the polypeptide Proteins • 25 T A B L E 2 – 3 ➤ CHARACTERISTICS OF HUMAN CRYSTALLINS Properties and names α β γ Subtypes αA, αB βL, βH Primary structure N-terminus N-terminus acetylated.

2See 41,399 39,049 2,114 284 348 ~66% mannose and N-acetyl glucosamine2 Lys # 296 Ser (near C-terminus) Asp (near N-terminus) 38 • Biochemistry of the Eye Figure 2–23 The absorption spectrum of rhodopsin and opsin. ➤ The spectra of intermediate forms are not shown. The γ-peak is characteristic of all proteins, while the β-peak is the absorption peak of unbound all-trans retinal and the α-peak is bound 11-cis retinal. bound to opsin (as rhodopsin). The β-peak (approximately 375 nm) is the absorption of all-trans retinal, which is not bound to opsin.

The absorptivity is a quantity that mathematically contains the physical-chemical characteristics of the sample and its surroundings. , experimentally). For example, the molar absorptivity of rhodopsin = 40,000 cm–1 M–1. The light pathlength is the distance that the light travels in passing through a sample and is usually 1 cm. This light passes through the sample in a special container known as a cuvette. The concentration of the sample is the most useful part of the equation inasmuch as it gives the amount of sample present in a given volume.

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Biochemistry of the Eye by David R. Whikehart PhD


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