Download PDF by Roger A. Barker, Neil Scolding, Dominic Rowe, Andrew J.: A-Z of Neurological Practice: A Guide to Clinical Neurology

By Roger A. Barker, Neil Scolding, Dominic Rowe, Andrew J. Larner

ISBN-10: 1848829930

ISBN-13: 9781848829930

ISBN-10: 1848829949

ISBN-13: 9781848829947

The moment version of A-Z of Neurological perform builds at the prior version withrevised and up-to-date details in a excessive density yet simply available structure to supply a brief and prepared reference for busy clinicians of all levels of expertise. Entries for particular neurological stipulations are uniformly based indicating: Pathophysiology; scientific positive factors; Investigations and prognosis; Differential analysis; therapy and analysis. Key references are stated all through and all entries are pass referenced.

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By Roger A. Barker, Neil Scolding, Dominic Rowe, Andrew J. Larner

ISBN-10: 1848829930

ISBN-13: 9781848829930

ISBN-10: 1848829949

ISBN-13: 9781848829947

The moment version of A-Z of Neurological perform builds at the prior version withrevised and up-to-date details in a excessive density yet simply available structure to supply a brief and prepared reference for busy clinicians of all levels of expertise. Entries for particular neurological stipulations are uniformly based indicating: Pathophysiology; scientific positive factors; Investigations and prognosis; Differential analysis; therapy and analysis. Key references are stated all through and all entries are pass referenced.

Show description

Read or Download A-Z of Neurological Practice: A Guide to Clinical Neurology PDF

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Extra resources for A-Z of Neurological Practice: A Guide to Clinical Neurology

Sample text

Though rare, the mortality of these conditions is very high. Amyloid diseases: overview Amyloid is the name given to predominantly extracellular fibrillar material composed primarily of protein, in the form of insoluble b-pleated sheets, the origin of which varies with the type of amyloidosis and disease state. Amyloid deposits are best visualized using the dye Congo red: light microscopy shows amyloid deposits to be pink or red in color, but under polarized light the Congo red-stained amyloid demonstrates an apple-green birefringence.

Investigation • Bedside testing: –– Pupillary responses to light. –– Postural blood pressure readings: a drop of >30/15 mmHg is significant if the patient is not fluid depleted. –– Heart rate response to standing: should consist of an increase in rate between 10–30 beats/min. –– Sweat test using quinizarin powder: should be positive when body temperature is raised by 1°C using space and electric blankets. –– Valsalva maneuver with ECG monitoring: should demonstrate an increase in heart rate and there should be variation in heart rate with respiration.

Reference Gibbs SDJ, Hawkins PN. Biochemical basis of the amyloid diseases. Br J Hosp Med. 2010;71:70–75 Andersen–Tawil syndrome [OMIM#170390] This is a rare disorder characterized by the following triad: • Periodic paralysis (hyperkalemic or hypokalemic). • Malignant ventricular arrhythmia; this may postdate the periodic paralysis by many years; there may be a prolonged QT interval on ECG (hence, may be classified with long QT syndromes, as LQT7). • Craniofacial dysmorphism: may be subtle. Mutations in the voltage-independent skeletal muscle potassium channel gene (KCNJ2) have been found in this condition; hence, it is a channelopathy.

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A-Z of Neurological Practice: A Guide to Clinical Neurology by Roger A. Barker, Neil Scolding, Dominic Rowe, Andrew J. Larner


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