By Robert H. Rosa Jr., MD
This quantity is split into elements: half I, Ophthalmic Pathology; and half II, Intraocular Tumors: medical features. half I makes use of a hierarchy that strikes from basic to precise to assist derive a differential prognosis for a selected tissue. half II is a compilation of chosen medical facets of value to the final ophthalmologist. Following half II are the yankee Joint Committee on melanoma 2010 staging kinds for ocular and adnexal tumors. This revised textual content comprises a variety of new pathologic and medical images. significant revision 2011-2012.
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Additional resources for 2011-2012 Basic and Clinical Science Course, Section 4: Ophthalmic Pathology and Intraocular Tumors (Basic & Clinical Science Course)
The response can be subdivided according to the time frame of symptoms and signs (ac ute or chron ic); accordi ng to the appearance of the conjun ctiva (papillary, follic ular, or less commo nly, granulomatous); or accordi ng to etiology (infectious, non in fect ious). See BCSC Section 6, Pediatric Ophthalmology and Strabismus, and Section 8, External Disease and Cornea, for additional discussion. Papillary Versus Follicular Conjunctivitis Most cases of conjunctivitis may be categorized as either papillary or foll icular, accord~ ing to the macroscopic and m icroscopic appearance of the conj unctiva (Fig 5 ~3) .
Note the paler, re latively larger, immature lymphocytes in the germ inal center, as compared to the darker, small, mature lymphocytes and plasma cells in the corona. (Parr A courtesy of Anthony J. Lubniewski, MD; part B courtes y of George J. ) Granulomatous Conjunctivitis Though less common than papillary or fo llicular conjunctivitis, granulomatous conjunc· tivitis does occur. Clinically. the nodular elevations observed in granu lomatous conjunc- tivitis may be difficult to distinguish from follicles, but clinical history and other systemic symptoms may point to th e diagnosis.
Molecular Pathology Molecular biology techniques are used increasingly in diagnostic ophthalmiC pathology and extensively in experimental pathology (Table 4-2). More recentl y, their use has expanded to include prognostication of disease and determination of treatment. Molecular path olog y is used to identify tumor-promoting or tumor-inhibiting genes (CGH, PCR, array CGH ), such as the retinoblastoma gene; and viral DNA or RNA strands, such as those seen in herpesviruses and Epstein-Barr virus (PCR, in situ hybridization [ISH ]) .
2011-2012 Basic and Clinical Science Course, Section 4: Ophthalmic Pathology and Intraocular Tumors (Basic & Clinical Science Course) by Robert H. Rosa Jr., MD